Change in Scope of Work
Any proposed change in the specific aims of the project as stated in the proposal or approved modifications, and/or any proposed change in the protocol, requires approval from the awarding agency. Examples of changes that require sponsor approval include, but are not limited to:
- Substitution of one animal mode for another
- Any change from the approved use of animals or human subjects
- Shifting the emphasis of the research from one disease area to another.
When in doubt, it is best to err on the side of over-communicating with the program office.